In developing the future of precision medicine, Eccrine is focused on closing the gap between population-based dosing protocols and individual drug response influenced by lifestyle, environment, and genetics.


Eccrine Systems’ personal drug response profiles will enable prescribers to optimize pharmacotherapy — helping to solve a $500B/year problem for U.S. healthcare.1


Using data insights derived from our medication monitoring platform, we are pioneering the field of Pharmacoeccrinology –– The study of personal drug response derived from the non-invasive and continuous measurement of drug and biomarker levels excreted in locally stimulated sweat.

 
iStock-182250161 (1).jpg

Pharmacoeccrinology goes beyond predicting which drugs are best for an individual patient based on genetic tests to knowing the personal drug response for each patient as administered. Precision medicine is the future, and individual drug response insights will be essential for drug therapy optimization —prescribing, precision dosing, and monitoring — as well as how drugs are developed and approved.

 

 

Pharmacoeccrinology

Addressing the variability in drug response

Traditional drug therapy follows standard dosing protocols derived from population studies with limited heterogeneity. Because patients metabolize drugs differently, individuals may experience a lack of drug effectiveness, increased non-adherence, adverse drug reactions, and subsequent treatments that burden patients, payers and healthcare systems.2

Individualized data insights derived from locally stimulated sweat via our non-invasive medication monitoring platform will move medicine toward...

  • Personalized dosing

  • Better clinical outcomes

  • Improved patient adherence

  • Reduction of adverse drug reactions

  • Managed overall cost of healthcare

iStock-898328226.jpg
 

 

Eccrine Breakthrough

Sweat PK analysis to enable personalized dosing

Sweat-blood correlation.  We have demonstrated that pharmacokinetics (PK) of a small molecule drug can be measured in locally stimulated sweat as correlated with its pharmacokinetics in blood.

Ease of process. To produce PK profiles, our non-invasive wearable device will measure personal drug response based on the changing drug levels excreted in locally stimulated eccrine sweat.  No sticks. No discomfort.

iStock_21348511_LARGE.jpg
 

 

Latest News


1. Watanabe, J.H., (2018) Cost of Prescription Drug-Related Morbidity and Mortality. Annals of Pharmacotherapy. Vol 52, Issue 9.

2. Peck, R.W., Precision Medicine Is Not Just Genomics: The Right Dose for Every Patient. Annual Review of Pharmacology and Toxicology. 2018. 58:105–22.